On Oct. 3, the Centers for Disease Control and Prevention (CDC) issued a health alert to inform clinicians and health departments that an outbreak of Marburg virus disease (MVD), a rare but highly fatal viral hemorrhagic fever, has occurred in the Republic of Rwanda. As of Oct. 15, 62 illnesses and 15 deaths from MVD have been reported. Though no confirmed MVD cases have yet been reported in the United States, travelers returning from Rwanda in the 21 days before symptom onset may have MVD and should be screened for risk factors related to their activities or contacts in Rwanda.